Benefits of Phosphatidylserine

Benefits of Phosphatidylserine

What is it?

Phosphatidylserine, or PS, is a compound similar to a dietary fat which is highly prevalent in human neural tissue. It can be synthesized as well as consumed through the diet , but further benefits can be gained through supplementation. Phosphatidylserine supplements are generally synthesized from soy, bovine, or sunflowers.  Our Premium Essentials Soy-Free Phosphatidylserine is synthesized from sunflowers.

Scientific Studies:

Attention, ADHD, and Cognition:

2 months of supplementation of 200mg Phosphatidylserine (PS) appears to improve symptoms of global and subscale attention deficit and hyperactivity disorders in children with ADHD, and secondary to improving symptoms of ADHD an improvement in short-term auditory memory and impulsivity was noted.

In otherwise healthy young adults given 400mg PS for 2 weeks, a significant improvement in processing speed (20%) and accuracy (13% more correct responses, 39% less wrong responses) is noted relative to placebo and independent of mood state.

One study of young golfers given 200mg phosphatidylserine for 42 days, showed a 21.6% increase in drive accuracy (percentage of straight shots).

Reduced Cognitive Decline:

Phosphatidylserine has been found to preserve glucose metabolism during Alzheimer's disease by 13.5–16% following ingestion of 500mg phosphatidylserine.

In studies assessing cognitive decline in Alzheimer's via the MMSE, there appears to be a collection of studies suggesting no effect with 500mg for 3 weeks but benefit with 300mg of phosphatidylserine for 8 weeks or 12 weeks and has been noted to have benefit with 400mg over 6 months to a level greater than Pyritinol. One study using the MMSE as a rating scale in elderly persons with age-related cognitive decline (but not diagnosed Alzheimer's) has also noted an improvement with 300mg phosphatidylserine.

In other cognitive disease states, persons with Parkinson's disease given phosphatidylserine noted some degree of improvement on EEG parameters and in general dementia 300mg of phosphatidylserine has noted some degree of benefit within 3 weeks of a 6 week trial and has improved memory and depressive symptoms in persons suffering from geriatric depression.

Learning and Memory:

The first report of cognitive improvement in elderly humans with aging associated mental impairment (non-pathological) was 3 months of 300mg soy-based phosphatidylserine (PS), in which scores on the Wechsler Memory test improved with particular improvement in visual memory; this was later replicated with 300mg PS over 12 weeks and two studies have noted that PS supplementation appears to aid in face recognition in elderly persons at this dose.

Exercise and Performance:

During intermittent moderate intensity cycling in which soy based phosphatidylserine was consumed for 10 days at 750mg noted that time to exhaustion increased by 29+/-8% when cycling at 85% intensity, and that this improvement was independent of any changes in fat oxidation or cortisol changes.



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